Inhibition of caspase activity induces a switch from apoptosis to necrosis

被引：167

作者：

Lemaire, C ^{[1
]}

Andréau, K ^{[1
]}

Souvannavong, V ^{[1
]}

Adam, A ^{[1
]}

机构：

[1] Univ Paris Sud, Inst Biochim, ERS 0571, CNRS, F-91405 Orsay, France

来源：

FEBS LETTERS | 1998年 / 425卷 / 02期

关键词：

caspase; caspase inhibitor; apoptosis; necrosis; dexamethasone; B lymphocyte;

D O I：

10.1016/S0014-5793(98)00252-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of caspases in B lymphocyte cell death was investigated by using two broad spectrum inhibitors of the caspase family, Z-Asp-cmk and Z-VAD-fmk. They totally prevented spontaneous and drug-induced apoptosis and inhibited the CPP32/caspase-3-like activity exhibited by apoptotic cells. However, the suppression of apoptosis was not associated with a long-term increase of cell survival, but conversely, with a switch from apoptotic death to the necrotic form. These results strongly suggest that apoptosis and necrosis share common initiation pathways, the final issue being determined by the presence of an active caspase. (C) 1998 Federation of European Biochemical Societies.

引用

页码：266 / 270

页数：5

共 32 条

[1] Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus [J].