Molecular characterization of the phenylacetic acid catabolic pathway in Pseudomonas putida U:: The phenylacetyl-CoA catabolon

被引：171

作者：

Olivera, ER

Miñambres, B

García, B

Muñiz, C

Moreno, MA

Ferrández, A

Díaz, E

García, JL

Luengo, JM ^{[1
]}

机构：

[1] Univ Leon, Fac Vet, Dept Bioquim & Biol Mol, Leon 24007, Spain

[2] CSIC, Ctr Invest Biol, Dept Mol Microbiol, E-28006 Madrid, Spain

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 11期

关键词：

D O I：

10.1073/pnas.95.11.6419

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fourteen different genes included in a DNA fragment of 18 kb are involved in the aerobic degradation of phenylacetic acid by Pseudomonas putida U. This catabolic pathway appears to be organized in three contiguous operons that contain the following functional units: (i) a transport system, (ii) a phenylacetic acid activating enzyme, (iii) a ring-hydroxylation complex, (iv) a ring-opening protein, (v) a P-oxidation like system, and (vi) two regulatory genes. This pathway constitutes the common part (core) of a complex functional unit (catabolon) integrated by several routes that catalyze the transformation of structurally related molecules into a common intermediate (phenylacetyl-CoA).

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页码：6419 / 6424

页数：6

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