Terbinafine hepatotoxicity: Case report and review of the literature

被引：31

作者：

Fernandes, NF

Geller, SA

Fong, TL

机构：

[1] Cedars Sinai Med Ctr, Ctr Liver Dis & Transplantat, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 1998年 / 93卷 / 03期

关键词：

D O I：

10.1111/j.1572-0241.1998.00459.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report a patient who developed significant liver dysfunction following therapy with terbinafine, At the end of a 3 1/2-wk course Of terbinafine, he developed progressive jaundice and pruritus. His serum bilirubin peaked at 30.9 mg/dl 3 wk after discontinuing terbinafine. A liver biopsy revealed mild to moderate mixed cellular infiltrate in the portal tracts, and hepatocellular and canicular cholestasis. His liver tests normalized 100 days after stopping terbinafine, (C) 1998 by Am. Cell. of Gastroenterology.

引用

页码：459 / 460

页数：2

共 9 条

[1]

ALLEN BR, 1989, BRIT J DERMATOL, V21, P16

[2] TERBINAFINE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN SUPERFICIAL MYCOSES [J].