Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

被引：300

作者：

Marsden, VS ^{[1
]}

Strasser, A ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Mol Genet Canc Div, Melbourne, Vic 3050, Australia

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2003年 / 21卷

关键词：

lymphocyte development; myeloid development; Fas; cell survival; repertoire selection;

D O I：

10.1146/annurev.immunol.21.120601.141029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptotic cell death plays a critical role in the development and functioning of the immune system. During differentiation, apoptosis weeds out lymphocytes lacking useful antigen receptors and those expressing dangerous ones. Lymphocyte death is also involved in limiting the magnitude and duration of immune responses to infection. In this review, we describe the role of the Bcl-2 protein family, and to a lesser extent that of death receptors (members of the tumor necrosis factor receptor family with a death domain), in the control of lymphoid and myeloid cell survival. We also consider the pathogenic consequences of failure of apoptosis in the immune system.

引用

页码：71 / 105

页数：35

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