Oncolytic viruses

被引：285

作者：

Chiocca, EA ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Mol Neurooncol Labs, Neurol Serv, Charlestown, MA 02129 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 12期

关键词：

D O I：

10.1038/nrc948

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile, and can be modified to direct their cytotoxicity towards cancer cells. These viruses are known as oncolytic viruses. How are viruses engineered to become tumour specific, and can they be used to safely treat cancer in humans?.

引用

页码：938 / 950

页数：13

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