MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2

被引：90

作者：

Feng, Shujun ^{[1
]}

Pan, Wenjing ^{[1
]}

Jin, Ye ^{[1
]}

Zheng, Jianhua ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Harbin 150001, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 12期

关键词：

Ovarian cancer; MiR-25; Proliferation; Migration; Invasion; TUMOR-SUPPRESSOR; CELL-MIGRATION; EXPRESSION; INVASION; GROWTH; PHOSPHORYLATION; ANGIOGENESIS; PROGRESSION; ANGIOMOTIN;

D O I：

10.1007/s13277-014-2546-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies suggest that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC and a potentially novel diagnostic and therapeutic target for OC treatment.

引用

页码：12339 / 12344

页数：6

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