Altered response to stimuli of the AP-1/DNA binding activity in a syndrome of precocious ageing (geroderma osteodysplastica hereditaria)

被引：4

作者：

Gherzi, R

Bellini, C

Bonioli, E

机构：

[1] Univ Genoa, Ist Clin Pediat, I-16147 Genoa, Italy

[2] Ist Nazl Ric Canc, Cell Biol Lab, I-16132 Genoa, Italy

[3] Univ Genoa, Ist Puericultura & Med Neonatale, I-16147 Genoa, Italy

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1998年 / 100卷 / 02期

关键词：

AP-1; fibroblasts; binding activity; GO17;

D O I：

10.1016/S0047-6374(97)00134-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell senescence produces changes in the expression of specific genes, suggesting that senescent cells express an altered pattern of transcription factors. Here we describe how the DNA binding activity of the activator protein 1(AP-1) complex is altered in the fibroblasts of a geroderma osteodysplastica patient in response to extracellular stimuli. (C) 1998 Elsevier Science Ireland Ltd.

引用

收藏

页码：169 / 175

页数：7

相关论文

共 19 条

[1] THE ROLE OF JUN, FOS AND THE AP-1 COMPLEX IN CELL-PROLIFERATION AND TRANSFORMATION [J].

ANGEL, P ;

KARIN, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1072 (2-3) :129-157

[2]

BAMATTER, 1950, ANN PEDIAT, V174, P126

[3] AP-1 ACTIVITY DURING NORMAL HUMAN KERATINOCYTE DIFFERENTIATION - EVIDENCE FOR A CYTOSOLIC MODULATOR OF AP-1 DNA-BINDING [J].

BRIATA, P ;

DANNA, F ;

FRANZI, AT ;

GHERZI, R .

EXPERIMENTAL CELL RESEARCH, 1993, 204 (01) :136-146

[4] ALTERATIONS IN THE MOLECULAR RESPONSE TO DNA-DAMAGE DURING CELLULAR AGING OF CULTURED FIBROBLASTS - REDUCED AP-1 ACTIVATION AND COLLAGENASE GENE-EXPRESSION [J].

CHOI, AMK ;

PIGNOLO, RJ ;

RHYS, CMJ ;

CRISTOFALO, VJ ;

HOLBROOK, NJ .

JOURNAL OF CELLULAR PHYSIOLOGY, 1995, 164 (01) :65-73

[5]

COVIELLO DA, 1990, AM J HUM GENET A, V204, P47

[6] EFFECT OF THE TUMOR PROMOTER PHORBOL 12-MYRISTATE 13-ACETATE (PMA) ON PROLIFERATION OF YOUNG AND SENESCENT WI-38 HUMAN-DIPLOID FIBROBLASTS [J].

DETATA, V ;

PTASZNIK, A ;

CRISTOFALO, VJ .

EXPERIMENTAL CELL RESEARCH, 1993, 205 (02) :261-269

[7] ALTERED PROFILE OF TRANSCRIPTION FACTOR-BINDING ACTIVITIES IN SENESCENT HUMAN FIBROBLASTS [J].

DIMRI, GP ;

CAMPISI, J .

EXPERIMENTAL CELL RESEARCH, 1994, 212 (01) :132-140

[8] Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B [J].

Helenius, M ;

Hanninen, M ;

Lehtinen, SK ;

Salminen, A .

BIOCHEMICAL JOURNAL, 1996, 318 :603-608

[9] TRANSCRIPTIONAL REGULATION BY EXTRACELLULAR SIGNALS - MECHANISMS AND SPECIFICITY [J].

HILL, CS ;

TREISMAN, R .

CELL, 1995, 80 (02) :199-211

[10] Altered expression and regulation of the alpha 5 beta 1 integrin-fibronectin receptor lead to reduced amounts of functional alpha 5 beta 1 heterodimer on the plasma membrane of senescent human diploid fibroblasts [J].

Hu, QB ;

Moerman, EJ ;

Goldstein, S .

EXPERIMENTAL CELL RESEARCH, 1996, 224 (02) :251-263