Altered response to stimuli of the AP-1/DNA binding activity in a syndrome of precocious ageing (geroderma osteodysplastica hereditaria)

被引：4

作者：

Gherzi, R

Bellini, C

Bonioli, E

机构：

[1] Univ Genoa, Ist Clin Pediat, I-16147 Genoa, Italy

[2] Ist Nazl Ric Canc, Cell Biol Lab, I-16132 Genoa, Italy

[3] Univ Genoa, Ist Puericultura & Med Neonatale, I-16147 Genoa, Italy

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1998年 / 100卷 / 02期

关键词：

AP-1; fibroblasts; binding activity; GO17;

D O I：

10.1016/S0047-6374(97)00134-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell senescence produces changes in the expression of specific genes, suggesting that senescent cells express an altered pattern of transcription factors. Here we describe how the DNA binding activity of the activator protein 1(AP-1) complex is altered in the fibroblasts of a geroderma osteodysplastica patient in response to extracellular stimuli. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：169 / 175

页数：7

共 19 条

[11] AN ALTERED REPERTOIRE OF FOS JUN (AP-1) AT THE ONSET OF REPLICATIVE SENESCENCE [J].