Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution

被引：24

作者：

Dudakov, Jarrod A. ^{[1
]}

Khong, Danika M. P. ^{[1
]}

Boyd, Richard L. ^{[1
]}

Chidgey, Ann P. ^{[1
]}

机构：

[1] Monash Univ, MISCL, Immune Regenerat Lab, Clayton, Vic 3800, Australia

来源：

TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 05期

基金：

英国医学研究理事会;

关键词：

HEMATOPOIETIC STEM-CELLS; COMMON LYMPHOID PROGENITORS; SELF-RENEWAL CAPACITY; GROWTH-FACTOR KGF; T-CELL; LINEAGE COMMITMENT; LYMPHOHEMATOPOIETIC PROGENITORS; MULTIPOTENT PROGENITORS; THYMOCYTE PROGENITORS; EPITHELIAL-CELLS;

D O I：

10.1016/j.it.2010.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Most of the steps of lymphopoiesis have been elucidated but contentious issues remain, particularly regarding the identity and function of the earliest lymphoid progenitors that leave the bone marrow and seed the thymus. Hematopoiesis is effectively continuous throughout life, but there is a profound decline in immune function with increasing age, driven by thymus involution and severely curtailed B cell development. A key question is whether defects in bone marrow progenitors, such as reduced differentiation and repopulation potential, are the common denominator. While thymic involution temporally precedes overt HSC functional decline, a logical supposition is that the latter exacerbates the former. This review explores this possible link, and concludes that improving bone marrow function is fundamental to sustained thymic regeneration.

引用

页码：191 / 198

页数：8

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