Multiple-antibiotic resistance mediated by structurally related IncL/M plasmids carrying an extended-spectrum β-lactamase gene and a class 1 integron

被引：81

作者：

Villa, L

Pezzella, C

Tosini, F

Visca, P

Petrucca, A

Carattoli, A

机构：

[1] Ist Super Sanita, Lab Bacteriol & Med Mycol, I-00161 Rome, Italy

[2] Ist Super Sanita, Lab Cellular Biol, I-00161 Rome, Italy

[3] Univ Roma Tre, Dipartimento Biol, Rome, Italy

[4] IRCCS Lazzaro Spallanzani, Rome, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 10期

关键词：

D O I：

10.1128/AAC.44.10.2911-2914.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A conjugative IncL/M plasmid (pSEM) conferring resistance to gentamicin, amikacin, kanamycin, sulfonamides, and expanded-spectrum cephalosporins was found in pathogenic strains of Salmonella enterica serotype Typhimurium. Resistance to aminoglycosides was encoded by a sul1-type class 1 integron (In-t3). An extended-spectrum beta-lactamase gene, bla(SHV-5), was identified 3.5 kb downstream of the integrase (intI1) gene of In-t3. Nucleotide sequence analysis of the 5.3-kb bla(SHV-5)-In-t3 region of pSEM highlighted striking similarities with IncL/M plasmids isolated from nosocomial gram-negative pathogens, conferring resistance to expanded-spectrum cephalosporins and aminoglycosides.

引用

页码：2911 / 2914

页数：4

共 29 条

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