Substituted E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones with antitumor activity.: Effect on the cell cycle and apoptosis

被引：26

作者：

Andreani, Aldo

Burnelli, Silvia

Granaiola, Massimiliano

Leoni, Alberto

Locatelli, Alessandra

Morigi, Rita

Rambaldi, Mirella

Varoli, Lucilla

Calonghi, Natalia

Cappadone, Concettina

Farruggia, Giovanna

Zini, Maddalena

Stefanelli, Claudio

Masotti, Lanfranco

机构：

[1] Univ Bologna, Dipartimento Sci Farmceut, I-40126 Bologna, Italy

[2] Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 14期

关键词：

D O I：

10.1021/jm070235m

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The synthesis and antitumor activity of new E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones is described. They were studied at the National Cancer Institute, taking into consideration the 50% growth inhibitory power (pGI(50)), the cytostatic effect (pTGI = total growth inhibition), and the cytotoxic effect (pLC(50)). All the compounds were potent growth inhibitors, with mean pGI(50) ranging from 5.26 to 7.72. They were also analyzed with NCI COMPARE algorithm. Further studies were dedicated to the effects on the cell cycle and apoptosis.

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收藏

页码：3167 / 3172

页数：6

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