Synthesis and antitumor activity of guanylhydrazones from 6-(2,4-dichloro-5-nitrophenyl)imidazo[2,1-b]thiazoles and 6-pyridylimidazo[2,1-b]thiazoles

被引：31

作者：

Andreani, Aldo

Burnelli, Silvia

Granaiola, Massimiliano

Leoni, Alberto

Locatelli, Alessandra

Morigi, Rita

Rambaldi, Mirella

Varoli, Lucilla

Farruggia, Giovanna

Stefanelli, Claudio

Masotti, Lanfranco

Kunkel, Mark W.

机构：

[1] Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy

[2] Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy

[3] NCI, Dev Therapeut Program, Informat Technol Branch, Div Canc Treatment & Diagnosis, Rockville, MD 20892 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 49卷 / 26期

关键词：

D O I：

10.1021/jm061077m

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The design and synthesis of antitumor imidazothiazole guanylhydrazones are reported. The compounds were submitted to NCI for testing. All but one were more active than methyl-GAG. A few compounds were selected for further studies in search of a possible mechanism of action. The results from these studies and a final search with the NCI COMPARE algorithm suggest that the guanylhydrazones described in this paper are acting through a novel mechanism of action.

引用

页码：7897 / 7901

页数：5

共 21 条

[1]

Potential antitumor agents. Part 29: Synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones [J].