Antitumor activity of substituted E-3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones

被引：62

作者：

Andreani, Aldo

Burnelli, Silvia

Granaiola, Massimiliano

Leoni, Alberto

Locatelli, Alessandra

Morigi, Rita

Rambaldi, Mirella

Varoli, Lucilla

Kunkel, Mark W.

机构：

[1] Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy

[2] NCI, Dev Therapeut Program, Informat Technol Branch, Div Canc Treatment & Diag, Bethesda, MD 20892 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 49卷 / 23期

关键词：

D O I：

10.1021/jm0607808

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design and synthesis of anticancer E-3-( 3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones is reported. Strong COMPARE correlations among the cell line responses suggest that these compounds may be acting similarly through a combination of different mechanisms of action. The 5-methoxy derivative ( 2h) was the most active compound with a mean pGI(50) of 6.34, and it is now under review by Biological Evaluation Committee of the National Cancer Institute for possible further studies.

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页码：6922 / 6924

页数：3

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