SYNTHESIS AND CARDIOTONIC ACTIVITY OF 2-INDOLINONES

被引：25

作者：

ANDREANI, A ^{[1
]}

RAMBALDI, M ^{[1
]}

LOCATELLI, A ^{[1
]}

BOSSA, R ^{[1
]}

GALATULAS, I ^{[1
]}

NINCI, M ^{[1
]}

机构：

[1] UNIV MILAN,FARMACOL ABT,I-20129 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 02期

关键词：

2-indolinone; cardiotonic activity;

D O I：

10.1016/0223-5234(90)90027-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The paper reports the synthesis of 3-(2,5-dimethoxybenzylidene)- 2 and 3-(4-pyridylmethylene)-2-indolinones 3 which, as expected, proved to have significant positive inotropic activity. On the contrary, 3-(2,5-dimethoxybenzyl)- 4 and 3-(4-pyridylmethyl)-2-indolinones 5, obtained by reduction of the corresponding compounds 2 and 3, were devoid of cardiotonic activity. © 1990.

引用

页码：187 / 190

页数：4

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