SYNTHESIS AND CARDIOTONIC ACTIVITY OF 2-INDOLINONES

被引：25

作者：

ANDREANI, A ^{[1
]}

RAMBALDI, M ^{[1
]}

LOCATELLI, A ^{[1
]}

BOSSA, R ^{[1
]}

GALATULAS, I ^{[1
]}

NINCI, M ^{[1
]}

机构：

[1] UNIV MILAN,FARMACOL ABT,I-20129 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 02期

关键词：

2-indolinone; cardiotonic activity;

D O I：

10.1016/0223-5234(90)90027-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The paper reports the synthesis of 3-(2,5-dimethoxybenzylidene)- 2 and 3-(4-pyridylmethylene)-2-indolinones 3 which, as expected, proved to have significant positive inotropic activity. On the contrary, 3-(2,5-dimethoxybenzyl)- 4 and 3-(4-pyridylmethyl)-2-indolinones 5, obtained by reduction of the corresponding compounds 2 and 3, were devoid of cardiotonic activity. © 1990.

引用

收藏

页码：187 / 190

页数：4

相关论文

共 60 条

[21] NONSTEROIDAL CARDIOTONICS .1. 2-PYRIDYL-6,7-DIHYDRO-3H,5H-PYRROLO[2,3-F]BENZIMIDAZOL-6-ONES, A NOVEL CLASS OF CARDIOTONIC AGENTS [J].

MERTENS, A ;

MULLERBECKMANN, B ;

KAMPE, W ;

HOLCK, JP ;

VONDERSAAL, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (08) :1279-1287

[22]

OGAWA H, 1988, CHEM PHARM BULL, V36, P2401

[23]

OGAWA H, 1988, CHEM PHARM BULL, V36, P2253

[24] A NOVEL CLASS OF CARDIOTONICS - SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF [4-(SUBSTITUTED-AMINO)PHENYL]PYRIDAZINONES AND RELATED DERIVATIVES [J].

OKUSHIMA, H ;

NARIMATSU, A ;

KOBAYASHI, M ;

FURUYA, R ;

TSUDA, K ;

KITADA, Y .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (07) :1157-1161

[25] DIHYDROPYRIDAZINONE CARDIOTONICS - SYNTHESIS AND INOTROPIC ACTIVITY OF 5'-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)SPIRO[CYCLOALKANE-1,3'-[3H]INDOL]-2'(1'H)-ONES [J].

ROBERTSON, DW ;

KRUSHINSKI, JH ;

POLLOCK, GD ;

WILSON, H ;

KAUFFMAN, RF ;

HAYES, JS .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (05) :824-829

[26] MOLECULAR-STRUCTURE OF THE DIHYDROPYRIDAZINONE CARDIOTONIC 1,3-DIHYDRO-3,3-DIMETHYL-5-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)-2H-INDOL-2-ONE, A POTENT INHIBITOR OF CYCLIC-AMP PHOSPHODIESTERASE [J].

ROBERTSON, DW ;

JONES, ND ;

KRUSHINSKI, JH ;

POLLOCK, GD ;

SWARTZENDRUBER, JK ;

HAYES, JS .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (04) :623-627

[27] IMIDAZOLE PYRIDINE BIOISOSTERISM - COMPARISON OF THE INOTROPIC ACTIVITIES OF PYRIDINE-SUBSTITUTED AND IMIDAZOLE-SUBSTITUTED 6-PHENYLDIHYDROPYRIDAZINONE CARDIOTONICS [J].

ROBERTSON, DW ;

KRUSHINSKI, JH ;

POLLOCK, GD ;

HAYES, JS .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (02) :461-465

[28] DIHYDROPYRIDAZINONE CARDIOTONICS - THE DISCOVERY AND INOTROPIC ACTIVITY OF 1,3-DIHYDRO-3,3-DIMETHYL-5-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)-2H-INDOL-2-ONE [J].

ROBERTSON, DW ;

KRUSHINSKI, JH ;

BEEDLE, EE ;

WYSS, V ;

POLLOCK, GD ;

WILSON, H ;

KAUFFMAN, RF ;

HAYES, JS .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (10) :1832-1840

[29] 4-AROYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES - A NEW CLASS OF CARDIOTONIC AGENTS .2. EFFECT OF 4-PYRIDOYL SUBSTITUENTS AND RELATED-COMPOUNDS [J].

SCHNETTLER, RA ;

DAGE, RC ;

PALOPOLI, FP .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (05) :860-862

[30] 4-AROYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES, A NEW CLASS OF CARDIOTONIC AGENTS [J].

SCHNETTLER, RA ;

DAGE, RC ;

GRISAR, JM .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (12) :1477-1481

← 1 2 3 4 5 6 →