Potential antitumor agents. Part 29: Synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones

被引：80

作者：

Andreani, A

Leoni, A

Locatelli, A

Morigi, R

Rambaldi, M

Recanatini, M

Garaliene, V

机构：

[1] Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy

[2] Lithuanian Inst Cardiol, LT-3007 Kaunas, Lithuania

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 09期

关键词：

D O I：

10.1016/S0968-0896(00)00165-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reports the synthesis of new imidazo[2,1-b]thiazole guanylhydrazones which were tested as potential antitumor agents. Three Of these derivatives (those bearing a 3- or 4-nitrophenyl group) were the most potent and one of these showed a mild effect as CDK I inhibitor. These same three derivatives were also tested as positive inotropic agents and two of them were more potent than amrinone at 10(- 5) M. These two guanylhydrazones could be useful coanthracyclinic agents. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：2359 / 2366

页数：8

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