DNA containing phenanthroline- and phenanthrene-derived, non-nucleosidic base surrogates

被引：16

作者：

Langenegger, SM ^{[1
]}

Häner, R ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 50期

关键词：

phenanthrene; phenanthroline; DNA; duplex; stacking;

D O I：

10.1016/j.tetlet.2004.10.068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simple, non-nucleosidic phenanthroline- and phenanthrene derivatives have been synthesised and incorporated into oligodeoxynucleotides. Complementary strands containing the modified building blocks in opposite positions form stable hybrids. Thermal denaturation experiments show that the double strands containing the phenanthroline derivatives are more stable than the ones with the corresponding phenanthrenes. Furthermore, it was found that duplex stability is considerably decreased if the linkers of the modified building blocks are too short. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9273 / 9276

页数：4

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