Transcriptional control of cell type and morphogenesis in Candida albicans

被引:68
作者
Whiteway, M
机构
[1] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada
[2] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada
关键词
D O I
10.1016/S1369-5274(00)00144-2
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Candida albicans has a number of transcriptional regulatory circuits that control aspects of cell type and cell morphogenesis. Recent work has uncovered a cryptic mating-type locus, and a variety of transcription factors that are important in regulation of the transition from yeast growth to hypha[ growth. In some cases, the signalling pathways regulating these transcription factors are becoming defined. Analysis of phenotypic switching implicates internal factors, as well as external signals, in control of cellular morphogenesis.
引用
收藏
页码:582 / 588
页数:7
相关论文
共 54 条
[11]   Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae [J].
Colombo, S ;
Ma, PS ;
Cauwenberg, L ;
Winderickx, J ;
Crauwels, M ;
Teunissen, A ;
Nauwelaers, D ;
de Winde, JH ;
Gorwa, MF ;
Colavizza, D ;
Thevelein, JM .
EMBO JOURNAL, 1998, 17 (12) :3326-3341
[12]   Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae [J].
Cook, JG ;
Bardwell, L ;
Kron, SJ ;
Thorner, J .
GENES & DEVELOPMENT, 1996, 10 (22) :2831-2848
[13]   Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis [J].
Csank, C ;
Schröppel, K ;
Leberer, E ;
Harcus, D ;
Mohamed, O ;
Meloche, S ;
Thomas, DY ;
Whiteway, M .
INFECTION AND IMMUNITY, 1998, 66 (06) :2713-2721
[14]   RIM101-dependent and -independent pathways govern pH responses in Candida albicans [J].
Davis, D ;
Wilson, RB ;
Mitchell, AP .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (03) :971-978
[15]  
Diener AC, 1996, GENETICS, V143, P769
[16]   Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans [J].
El Barkani, A ;
Kurzai, O ;
Fonzi, WA ;
Ramon, A ;
Porta, A ;
Frosch, M ;
Mülschlegel, FA .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (13) :4635-4647
[17]   Transcription factors in Candida albicans -: environmental control of morphogenesis [J].
Ernst, JF .
MICROBIOLOGY-SGM, 2000, 146 :1763-1774
[18]   Ras signaling is required for serum-induced hyphal differentiation in Candida albicans [J].
Feng, QH ;
Summers, E ;
Guo, B ;
Fink, G .
JOURNAL OF BACTERIOLOGY, 1999, 181 (20) :6339-6346
[19]   Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth [J].
Gavrias, V ;
Andrianopoulos, A ;
Gimeno, CJ ;
Timberlake, WE .
MOLECULAR MICROBIOLOGY, 1996, 19 (06) :1255-1263
[20]   A REGULATORY HIERARCHY FOR CELL SPECIALIZATION IN YEAST [J].
HERSKOWITZ, I .
NATURE, 1989, 342 (6251) :749-757