A transposon carrying the gene mphB for macrolide 2′-phosphotransferase II

被引：27

作者：

Noguchi, N ^{[1
]}

Katayama, J ^{[1
]}

Sasatsu, M ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Dept Microbiol, Tokyo 1920392, Japan

来源：

FEMS MICROBIOLOGY LETTERS | 2000年 / 192卷 / 02期

关键词：

macrolide resistance; mphB; transposon; Tn21; subgroup;

D O I：

10.1016/S0378-1097(00)00429-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

The mphB gene for macrolide 2'-phosphotransferase II is located on two plasmids, pTZ3721 and pTZ3723, in Escherichia coli BM2506. We examined translocation of mphB that originated from pTZ3721. The transposable element carrying mphB is 39 kb long and has a Tn21-like transposition module at one end and a Tn1721-like transposition module at other. The structure of the transposition modules of this element resembles that of Tn2610. However: the gene arrangement of the internal region on the transposon carrying mphB was reverse to that of Tn2610. The nucleotide sequences of both terminal regions suggested that the inversion of the DNA fragment occurred between the res sites by resolvase-mediated recombination. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：175 / 178

页数：4

共 18 条

[1]

COMPLETE NUCLEOTIDE-SEQUENCE OF TN1721 - GENE ORGANIZATION AND A NOVEL GENE-PRODUCT WITH FEATURES OF A CHEMOTAXIS PROTEIN [J].