The evolutionary origin of genetic instability in cancer development

被引：68

作者：

Breivik, J ^{[1
]}

机构：

[1] Norwegian Radium Hosp, Sect Immunotherapy, Oslo, Norway

[2] Univ Oslo, Fac Med, Med Res Curriculum, NO-0315 Oslo, Norway

来源：

SEMINARS IN CANCER BIOLOGY | 2005年 / 15卷 / 01期

关键词：

cancer; genetic instability; evolution; DNA repair; mutagens;

D O I：

10.1016/j.semcancer.2004.09.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The standard model of carcinogenesis is currently being questioned. The main controversy concerns genetic instability and has links to fundamental questions in evolutionary biology. This paper aims to clarify the underlying conflict between the linear configuration of the standard model and the non-linear dynamics of Darwinian evolution. It addresses the problem of applying the concept of clonal selection to genetically unstable cells and presents an alternative perspective based on the principles of molecular evolution. This model explains genetic instability in terms of competition between genetic strategies and draws lines to basic aspects of evolutionary biology. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：51 / 60

页数：10

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