Prolactin mediates photoperiodic immune enhancement: effects of administration of exogenous prolactin on circulating concentrations, receptor expression, and immune function in steers

被引:19
作者
Auchtung, TL [1 ]
Dahl, GE [1 ]
机构
[1] Univ Illinois, Dept Anim Sci, Anim Sci Lab 230, Urbana, IL 61801 USA
关键词
circadian rhythm; immune; immunology; photoperiod; prolactin; prolactin receptor; sensitivity;
D O I
10.1095/biolreprod.104.031005
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Changes in photoperiod can significantly impact the physiology of many species. For example, we have observed an improvement in cellular immune function in cattle on short-day photoperiod (SDPP) relative to long-day photoperiod (LDPP). In addition, prolactin (PRL) and PRL receptor (PRL-R) are affected by photoperiod management. Our hypothesis is that the inverse relationship observed between PRL and PRL-R mRNA expression during photoperiod treatment alters the sensitivity of the animal to PRL, thereby affecting the changes in their cellular immune function. The objective of this study was to determine the effects of exogenous PRL on photoperiodic-mediated immune responses. Eight Holstein steers received each of four treatments: LDPP (1161-:8D), SDPP (8L:D), SDom (SDPP plus PRL via osmotic minipump for 10 days), and SDinj (SDPP plus PRL via 3x daily injections for 10 days). Steers on SDPP had decreased PRL relative to the other treatments. Expression of PRL-R mRNA was increased in SDPP animals relative to LDPP, SDom, and SDinj. Prior to PRL treatment, SDPP animals had greater lymphocyte proliferation and neutrophil chemotaxis relative to LDPP animals. Following PRL treatment, cellular immune function of SDom and SDinj animals was reduced to the level of LDPP animals. Addition of PRL to the in vitro lymphocyte proliferation did not after response of LDPP animals but increased proliferation of lymphocytes from SDPP animals. The results of these experiments suggest that an animal's responsiveness to PRL correlate to changes in cellular immune function that occur with photoperiod manipulation.
引用
收藏
页码:1913 / 1918
页数:6
相关论文
共 24 条
[1]  
AKERS RM, 1980, P SOC EXP BIOL MED, V164, P115, DOI 10.3181/00379727-164-40833
[2]   Photoperiod and bromocriptine treatment effects on expression of prolactin receptor mRNA in bovine liver, mammary gland and peripheral blood lymphocytes [J].
Auchtung, TL ;
Kendall, PE ;
Salak-Johnson, JL ;
McFadden, TB ;
Dahl, GE .
JOURNAL OF ENDOCRINOLOGY, 2003, 179 (03) :347-356
[3]  
AUCHTUNG TL, 2003, J DAIRY SCI S1, V86, P410
[4]   Regulation of the immunoglobulin G1 receptor:: effect of prolactin on in vivo expression of the bovine mammary immunoglobulin G1 receptor [J].
Barrington, GM ;
Besser, TE ;
Gay, CC ;
Davis, WC ;
Reeves, JJ ;
McFadden, TB ;
Akers, RM .
JOURNAL OF ENDOCRINOLOGY, 1999, 163 (01) :25-31
[5]   HYPOPHYSEAL RESPONSES TO CONTINUOUS AND INTERMITTENT DELIVERY OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE [J].
BELCHETZ, PE ;
PLANT, TM ;
NAKAI, Y ;
KEOGH, EJ ;
KNOBIL, E .
SCIENCE, 1978, 202 (4368) :631-633
[6]   Short day lengths attenuate the symptoms of infection in Siberian hamsters [J].
Bilbo, SD ;
Drazen, DL ;
Quan, N ;
He, LL ;
Nelson, RJ .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2002, 269 (1490) :447-454
[7]  
Buckley Arthur R., 2000, V917, P522
[8]   Prolactin receptor signal transduction in cells of the immune system [J].
Clevenger, CV ;
Freier, DO ;
Kline, JB .
JOURNAL OF ENDOCRINOLOGY, 1998, 157 (02) :187-197
[9]   Environmental modulation of the immune system via the endocrine system [J].
Davis, SL .
DOMESTIC ANIMAL ENDOCRINOLOGY, 1998, 15 (05) :283-289
[10]   REGULATION OF PROLACTIN RECEPTOR MESSENGER-RNA EXPRESSION IN PERIPHERAL LYMPHOCYTES IN RATS IN RESPONSE TO CHANGES IN SERUM CONCENTRATIONS OF PROLACTIN [J].
DICARLO, R ;
BOLEFEYSOT, C ;
GUALILLO, O ;
MELI, R ;
NAGANO, M ;
KELLY, PA .
ENDOCRINOLOGY, 1995, 136 (10) :4713-4716