Synthesis of 15β-hydroxyalkyl-substituted (17Z)-pregn-17-enes, their ethers and esters

被引：3

作者：

Baranovskii, A ^{[1
]}

Litvinovskaya, RP ^{[1
]}

Khripach, VA ^{[1
]}

机构：

[1] Natl Acad Sci, Inst Bioorgan Chem, Minsk 220141, BELARUS

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 40卷 / 11期

关键词：

D O I：

10.1007/s11178-005-0067-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Proceeding from Delta(15)-17-ketosteroids via copper(l)-catalyzed 1,4-addition of Grignard reagent followed by modification of the 15-alkenyl substituent, introduction of a 17-ethylidene component via Wittig reaction, and transformations in the A and B rings of the steroid molecule we obtained a series of 15beta-hydroxyalkyl-substituted (17Z)-pregn-17-enes, their ethers and esters.

引用

页码：1608 / 1616

页数：9

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