AN OXY-COPE REARRANGEMENT APPROACH TO C(15) ALPHA-ALKYLATED DERIVATIVES OF ESTRADIOL

被引：10

作者：

BOJACK, G ^{[1
]}

KUNZER, H ^{[1
]}

机构：

[1] SCHERING AG,RES LABS,D-13342 BERLIN,GERMANY

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 48期

关键词：

D O I：

10.1016/0040-4039(94)88417-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of C(15) allyl-substituted estrone derivatives 3 and 4 has been accomplished. Starting with 1 as a common precursor, 3 was made available in two steps by allylmagnesium halide addition to C(17) and subsequent oxy-Cope rearrangement, while the epimer 4 emerged from a Cu(I)-mediated 1,4-addition. The utility of intermediates 3 and 4 is highlighted in the construction of potential estrogen receptor agonists/antagonists 5, 6, and 11.

引用

页码：9025 / 9026

页数：2

共 19 条

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[2]

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[3]

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