Three-component, stereoselective palladium-catalyzed synthesis of functionalized bicyclopentanoids

被引：8

作者：

Hulin, B ^{[1
]}

Newton, LS ^{[1
]}

Cabral, S ^{[1
]}

Walker, AJ ^{[1
]}

Bordner, J ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Groton, CT 06340 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 23期

关键词：

D O I：

10.1021/ol048140r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,5-Cyclooctadiene can be stereoselectively transformed into a substituted bicyclo[3.3.0]octane ring system under palladium catalysis with concomitant formation of three carbon-carbon bonds. Reaction with an aryl iodide or triflate and malonate gives an exo-endo product, while the reaction with a malonate in the presence of oxygen affords a bis-endo adduct.

引用

页码：4343 / 4345

页数：3

共 33 条

[31] SELECTIVITIES IN ORGANIC-REACTIONS VIA PI-ALLYLPALLADIUM COMPLEXES [J].