Autophagy induction rescues toxicity mediated by proteasomem inhibition

被引：44

作者：

Rubinsztein, David C. ^{[1
]}

机构：

[1] Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 0XY, England

来源：

NEURON | 2007年 / 54卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.neuron.2007.06.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ubiquitin-proteasome and macroautophagy-lysosome pathways are major routes for intracytosolic protein degradation. In many systems, proteasome inhibition is toxic. A Nature article by Pandey et al. shows that this toxicity can be modulated by altering autophagic activity. Their tantalizing results suggest that overexpression of HDAC6 may increase flux through the autophagy pathway, thereby attenuating the toxicity resulting from proteasome inhibition.

引用

页码：854 / 856

页数：3

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