ACE inhibitory activity and characteristics of tri-peptides obtained from bonito protein

被引：7

作者：

Hasan, Md. Fida

Kobayashi, Yuka

Kumada, Yoichi

Katsuda, Tomohisa

Terashima, Masaaki

Katoh, Shigeo ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Sci & Technol, Kobe, Hyogo 6578501, Japan

[2] Okayama Univ, Dept Biosci & Biotechnol, Okayama 7008530, Japan

[3] Kobe Coll, Dept Biosphere Sci, Nishinomiya, Hyogo 6628505, Japan

来源：

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN | 2007年 / 40卷 / 01期

关键词：

angiotensin-I converting enzyme; inhibitory peptide; competitive inhibitor; digestion; bonito protein;

D O I：

10.1252/jcej.40.59

中图分类号：

TQ [化学工业];

学科分类号：

0817 [化学工程与技术];

摘要：

Inhibition characteristics of tri-peptides IKW and IKY, which were obtained as angiotensin-I converting enzyme inhibitors from bonito protein, and their stability in digestive canal were studied. These IKW and IKY showed high inhibitory activities with IC50 of 0.4 and 1.0 mu M, respectively, and acted as competitive inhibitors. The tri-peptides, especially IKY, were very stable under simulated gastrointestinal digestion conditions.

引用

页码：59 / 62

页数：4

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