Genetics, pathogenesis and clinical interventions in type 1 diabetes

被引：885

作者：

Bluestone, Jeffrey A. ^{[1
,2
]}

Herold, Kevan ^{[3
]}

Eisenbarth, George ^{[4
]}

机构：

[1] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Yale Univ, Dept Immunobiol, New Haven, CT 06520 USA

[4] Univ Colorado, Barbara Davis Ctr Childhood Diabet, Aurora, CO 80045 USA

来源：

NATURE | 2010年 / 464卷 / 7293期

关键词：

REGULATORY T-CELLS; ANTI-CD3; MONOCLONAL-ANTIBODY; B-LYMPHOCYTE DEPLETION; NOD MICE; RECENT-ONSET; COMBINATION THERAPY; PANCREATIC-ISLETS; INCREASED RISK; SINGLE COURSE; HUMAN THYMUS;

D O I：

10.1038/nature08933

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type 1 diabetes is an autoimmune disorder afflicting millions of people worldwide. Once diagnosed, patients require lifelong insulin treatment and can experience numerous disease-associated complications. The last decade has seen tremendous advances in elucidating the causes and treatment of the disease based on extensive research both in rodent models of spontaneous diabetes and in humans. Integrating these advances has led to the recognition that the balance between regulatory and effector T cells determines disease risk, timing of disease activation, and disease tempo. Here we describe current progress, the challenges ahead and the new interventions that are being tested to address the unmet need for preventative or curative therapies.

引用

页码：1293 / 1300

页数：8

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