Cell-mediated delivery of synthetic nano- and microparticles

被引：84

作者：

Ayer, Maxime

Klok, Harm-Anton ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Mat, Batiment MXD,Stn 12, CH-1015 Lausanne, Switzerland

来源：

JOURNAL OF CONTROLLED RELEASE | 2017年 / 259卷

基金：

瑞士国家科学基金会;

关键词：

Nano- and microparticles; Cellular backpacks; Cell surface-conjugation; Cellular hitchhiking; Cell-mediated drug delivery; MESENCHYMAL STEM-CELLS; STIMULI-RESPONSIVE NANOCARRIERS; TRAIL-COATED LEUKOCYTES; NATURAL-KILLER-CELLS; RED-BLOOD-CELLS; CARBON NANOTUBES; DRUG-DELIVERY; IMMUNE CELLS; GENE-THERAPY; NK CELLS;

D O I：

10.1016/j.jconrel.2017.01.048

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to explore cell surface modification strategies for the cellular hitchhiking of synthetic nano-and microparticles. The first part of this article will present and discuss the different types of cells that have been explored for cell mediated drug delivery. The second part of this review will discuss the various chemical strategies that have been elaborated for the conjugation or immobilization of nano-and microparticles on the surface of these cells. (C) 2017 Elsevier B.V. All rights reserved.

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页码：92 / 104

页数：13

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