Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: A critical review

被引：25

作者：

da Silva, Janine Mayra ^{[1
]}

Soave, Danilo Figueiredo ^{[2
]}

Moreira dos Santos, Talita Pollyanna ^{[1
]}

Batista, Aline Carvalho ^{[2
]}

Russo, Remo Castro ^{[3
]}

Teixeira, Mauro Martins ^{[4
]}

da Silva, Tarcilia Aparecida ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Odontol, Dept Oral Surg & Pathol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Goias, Fac Odontol, Dept Stomatol Oral Pathol, Goiania, Go, Brazil

[3] Univ Fed Minas, Inst Ciencias Biol, Dept Physiol & Biophys, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas, Inst Ciencias Biol, Dept Biochem & Immunol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

ORAL ONCOLOGY | 2016年 / 56卷

关键词：

Head and neck squamous cell carcinoma; Chemokines; Inflammation; LYMPH-NODE METASTASIS; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN MONOCLONAL-ANTIBODY; RANK LIGAND EXPRESSION; CARLUMAB CNTO 888; TUMOR-GROWTH; MACROPHAGE INFILTRATION; PROMOTES ANGIOGENESIS; FACTOR-1/CXCR4; SYSTEM; CXCR4; EXPRESSION;

D O I：

10.1016/j.oraloncology.2016.02.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Chemokines are small chemotactic proteins that coordinate circulation of immune/inflammatory cells throughout body compartments. Because of this property chemokines and their cell surface receptors are implicated in several physiological and pathological conditions, including cancer. These molecules are expressed by neoplastic or stromal cells and have effects at tumor primary site (e.g. stimulating angiogenesis and tumor cells motility) and lymph nodes (creating a gradient to direct migration of neoplastic cells). In this article we review the current knowledge about the function(s) of chemokines and receptors in squamous cell carcinoma from the oral cavity and head and neck region. Accumulating evidence suggests some chemokine(s) and receptor(s) as potential targets in adjuvant therapies for these malignancies. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：8 / 16

页数：9

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