Characterization of attenuated coxsackievirus B3 strains and prospects of their application as live-attenuated vaccines

被引：27

作者：

Kim, Dae-Sun ^{[1
]}

Nam, Jae-Hwan ^{[1
]}

机构：

[1] Catholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyunggi Do, South Korea

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2010年 / 10卷 / 02期

关键词：

attenuation; coxsackievirus B3; vaccine; TEMPERATURE-SENSITIVE MUTANTS; INFECTIOUS CDNA COPY; T-CELL-RECEPTOR; B3-INDUCED MYOCARDITIS; DNA VACCINE; BALB/C MICE; 5'-NONTRANSLATED REGION; MONOCLONAL-ANTIBODY; HUMAN RHINOVIRUS-14; VIRUS-REPLICATION;

D O I：

10.1517/14712590903379502

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Coxsackievirus strain CVB3 is widespread in the human population and causes myocarditis or pancreatitis. However, despite its clinical impact, there is no commercially available and clinically applicable prophylactic vaccine. This study examines the characteristics of attenuated CVB3 strains developed so far and their application as live-attenuated CVB3 vaccines, and discusses problems to be overcome in the development of live-attenuated vaccines.

引用

页码：179 / 190

页数：12

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