Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

被引：318

作者：

Park, YD

Tirelli, N

Hubbell, JA

机构：

[1] Swiss Fed Inst Technol, Dept Mat, Inst Biomed Engn, CH-8044 Zurich, Switzerland

[2] Univ Zurich, CH-8044 Zurich, Switzerland

来源：

BIOMATERIALS | 2003年 / 24卷 / 06期

关键词：

hyaluronic acid; hydrogels; photopolymerization; RGD; cell adhesion;

D O I：

10.1016/S0142-9612(02)00420-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7d, showing adhesion and proliferation only with incorporated RGD. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：893 / 900

页数：8