Ribosomal RNA processing and ribosome biogenesis in eukaryotes

被引：86

作者：

Nazar, RN ^{[1
]}

机构：

[1] Univ Guelph, Dept Mol Biol & Genet, Guelph, ON N1G 2W1, Canada

来源：

IUBMB LIFE | 2004年 / 56卷 / 08期

关键词：

ribosomes; eukaryotes; nucleolus; rRNA; RNA processing; snoRNA; nucleolar proteins;

D O I：

10.1080/15216540400010867

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotes nearly 500 rRNAs, ribosomal proteins, snoRNAs and trans-acting factors contribute to ribosome biogenesis. After more than 30 years of intense research, the incredible complexities of nucleolar function are revealed but details often remain unclear. Here we review this progress and the many intriguing questions which remain.

引用

页码：457 / 465

页数：9

共 77 条

[1] A RAC protein-binding site in the internal transcribed spacer 2 of pre-rRNA transcripts from Schizosaccharomyces pombe [J].

Abeyrathne, PD ;

Lalev, AI ;

Nazar, RN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21291-21299

[2] RNase III cleaves eukaryotic preribosomal RNA at a U3 snoRNP-dependent site [J].

AbouElela, S ;

Igel, H ;

Ares, M .

CELL, 1996, 85 (01) :115-124

[3] Functions of the exosome in rRNA, snoRNA and snRNA synthesis [J].

Allmang, C ;

Kufel, J ;

Chanfreau, G ;

Mitchell, P ;

Petfalski, E ;

Tollervey, D .

EMBO JOURNAL, 1999, 18 (19) :5399-5410

[4] Guiding ribose methylation of rRNA [J].

Bachellerie, JP ;

Cavaille, J .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (07) :257-261

[5] Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2′-O-ribose methylation of a conserved rRNA position in yeast [J].

Bonnerot, C ;

Pintard, L ;

Lutfalla, G .

MOLECULAR CELL, 2003, 12 (05) :1309-1315

[6] A small nucleolar RNP protein is required for pseudouridylation of eukaryotic ribosomal RNAs [J].

BousquetAntonelli, C ;

Henry, Y ;

Gelugne, JP ;

CaizerguesFerrer, M ;

Kiss, T .

EMBO JOURNAL, 1997, 16 (15) :4770-4776

[7]

Charette M, 2000, IUBMB LIFE, V49, P341

[8]

Cheutin T, 2002, J CELL SCI, V115, P3297

[9] Dynamic conformational model for the role of ITS2 in pre-rRNA processing in yeast [J].

Côte, CA ;

Greer, CL ;

Peculis, BA .

RNA, 2002, 8 (06) :786-797

[10] SEQUENCE ORGANIZATION AND RNA STRUCTURAL MOTIFS DIRECTING THE MOUSE PRIMARY RIBOSOMAL-RNA-PROCESSING EVENT [J].

CRAIG, N ;

KASS, S ;

SOLLNERWEBB, B .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (01) :458-467

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