Cell-cycle checkpoint kinases: checking in on the cell cycle

被引：115

作者：

Walworth, NC ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(00)00154-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice, in addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.

引用

收藏

页码：697 / 704

页数：8

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