4-methyl-1,2,3-selenadiazole-5-carboxylic acid amides: Antitumor action and cytotoxic effect correlation

被引：38

作者：

Arsenyan, Pavel ^{[1
]}

Rubina, Kira ^{[1
]}

Shestakova, Irina ^{[1
]}

Domracheva, Ilona ^{[1
]}

机构：

[1] Latvian Inst Organ Synthesis, Dept Med Chem, LV-1006 Riga, Latvia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 05期

关键词：

selenium; 1,2,3-selenadiazole; cytotoxic activity; morphology;

D O I：

10.1016/j.ejmech.2006.12.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and cytotoxic activity of a series of 4-methyl-1,2,3-selenadiazole-5-carboxylic acid amides on human fibrosarcoma HT-1080, mouse hepatoma MG-22A, and mouse fibroblasts 3T3 cell lines are described. The correlation between compound LD50 and 3T3 fibroblast cell line morphology was shown. In vivo evaluation of amides on mouse sarcoma S-180 confirms high antitumor activity (58-85%). (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：635 / 640

页数：6

共 20 条

[1] Selenium and cancer: Some nutritional aspects [J].

Alaejos, MS ;

Romero, FJD ;

Romero, CD .

NUTRITION, 2000, 16 (05) :376-383

[2] Synthesis and cytotoxicity of silylalkylthio-substituted N-heterocycles and their hydroselenites [J].

Arsenyan, P ;

Rubina, K ;

Shestakova, I ;

Abele, E ;

Abele, R ;

Domracheva, I ;

Nesterova, A ;

Popelis, J ;

Lukevics, E .

APPLIED ORGANOMETALLIC CHEMISTRY, 2003, 17 (11) :825-830

[3] Organoammonium hydroselenites: antitumor action through radical balance regulation [J].

Arsenyan, P ;

Shestakova, I ;

Rubina, K ;

Domracheva, I ;

Nesterova, A ;

Vosele, K ;

Pudova, O ;

Lukevics, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 465 (03) :229-235

[4]

ARSENYAN P, 2002, CHEM HETEROCYCL COMP, P1627

[5]

Bauer G, 2000, HANDB EXP PHARM, V142, P275

[6]

CAFFREY PB, 1991, MOL PHARMACOL, V39, P281

[7] Sensitivity of melphalan-resistant tumors to selenite in vivo [J].

Caffrey, PB ;

Frenkel, GD .

CANCER LETTERS, 1997, 121 (02) :177-180

[8] CRYSTALLINE BOVINE LIVER CATALASE [J].

EVENTOFF, W ;

TANAKA, N ;

ROSSMANN, MG .

JOURNAL OF MOLECULAR BIOLOGY, 1976, 103 (04) :799-801

[9] NITRIC-OXIDE PRODUCTION BY TUMOR TARGETS IN RESPONSE TO TNF - PARADOXICAL CORRELATION WITH SUSCEPTIBILITY TO TNF-MEDIATED CYTOTOXICITY WITHOUT DIRECT INVOLVEMENT IN THE CYTOTOXIC MECHANISM [J].

FAST, DJ ;

LYNCH, RC ;

LEU, RW .

JOURNAL OF LEUKOCYTE BIOLOGY, 1992, 52 (03) :255-261

[10] Meat, cancer and dietary advice to the public [J].

Hill, M .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2002, 56 (Suppl 1) :S36-S41

← 1 2 →