Location, location, location: important for jet-lagged circadian loops

被引:24
作者
Harrington, Mary [1 ]
机构
[1] Smith Coll, Dept Psychol, Northampton, MA 01063 USA
关键词
SUPRACHIASMATIC NUCLEUS; PERIPHERAL-TISSUES; TIMING SYSTEM; EXPRESSION; SHIFT; MICE; REENTRAINMENT; CLOCKS; LIGHT; WORK;
D O I
10.1172/JCI43632
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
It is now believed that frequent jet lag or shifts of daily rhythms caused by rotating shift work can lead to deleterious health outcomes. Indeed, many serious health problems, including breast cancer, stroke, and cardiovascular disease, have been linked to an occupational history of shift work. This has heightened interest in better understanding the biological responses to jet lag and shift work, with the hope that this will pave the way to developing compounds that can help people avoid their negative health consequences. In this context, a report in this issue of the JCI takes us to a new level of understanding of the molecular control of the resetting of the multitude of internal biological clocks disrupted in a mouse model of jet lag.
引用
收藏
页码:2265 / 2267
页数:3
相关论文
共 22 条
[1]  
Agostino PV, 2007, P NATL ACAD SCI USA, V104, P9834, DOI 10.1073/pnas.0703388104
[2]   Resetting of circadian time peripheral tissues by glucocorticoid signaling [J].
Balsalobre, A ;
Brown, SA ;
Marcacci, L ;
Tronche, F ;
Kellendonk, C ;
Reichardt, HM ;
Schütz, G ;
Schibler, U .
SCIENCE, 2000, 289 (5488) :2344-2347
[3]   Chronic jet-lag increases mortality in aged mice [J].
Davidson, A. J. ;
Sellix, M. T. ;
Daniel, J. ;
Yamazaki, S. ;
Menaker, M. ;
Block, G. D. .
CURRENT BIOLOGY, 2006, 16 (21) :R914-R916
[4]   Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system [J].
Davidson, Alec J. ;
Castanon-Cervantes, Oscar ;
Leise, Tanya L. ;
Molyneux, Penny C. ;
Harrington, Mary E. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2009, 29 (01) :171-180
[5]   Taking the Lag out of Jet Lag through Model-Based Schedule Design [J].
Dean, Dennis A., II ;
Forger, Daniel B. ;
Klerman, Elizabeth B. .
PLOS COMPUTATIONAL BIOLOGY, 2009, 5 (06)
[6]   The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks [J].
Dibner, Charna ;
Schibler, Ueli ;
Albrecht, Urs .
ANNUAL REVIEW OF PHYSIOLOGY, 2010, 72 :517-549
[7]   Effects of chronic jet lag on tumor progression in mice [J].
Filipski, E ;
Delaunay, F ;
King, VM ;
Wu, MW ;
Claustrat, B ;
Gréchez-Cassiau, A ;
Guettier, C ;
Hastings, MH ;
Francis, L .
CANCER RESEARCH, 2004, 64 (21) :7879-7885
[8]   NAN-190 potentiates the circadian response to light and speeds re-entrainment to advanced light cycles [J].
Kessler, E. J. ;
Sprouse, J. ;
Harrington, M. E. .
NEUROSCIENCE, 2008, 154 (04) :1187-1194
[9]   Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag [J].
Kiessling, Silke ;
Eichele, Gregor ;
Oster, Henrik .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (07) :2600-2609
[10]   Health disorders of shift workers [J].
Knutsson, A .
OCCUPATIONAL MEDICINE-OXFORD, 2003, 53 (02) :103-108