Radicals in enzymatic reactions

被引：34

作者：

Frey, PA ^{[1
]}

机构：

[1] Univ Wisconsin, Inst Enzyme Res, Madison, WI 53705 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(97)80072-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spectroscopic and kinetic evidence for-substrate-based radicals in the reactions of lysine 2,3-aminomutase and methane monooxygenase has recently been gathered. Evidence for a protein-based thiyl radical in the mechanism of the action of ribonucleotide reductase has been correlated with the proposed mechanism involving substrate-based radicals. Controversies have arisen about the mechanisms of ribonucleotide reductase and methane monooxygenase reactions.

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页码：347 / 356

页数：10

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