Synthesis of acyclic nucleoside phosphonates as antiviral compounds

被引：6

作者：

Wormstädt, F

Brinckmann, U

Gütschow, M

Eger, K

机构：

[1] Univ Leipzig, Inst Pharm Pharmazeut Chem, D-04103 Leipzig, Germany

[2] Univ Leipzig, Inst Virol, D-04103 Leipzig, Germany

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2000年 / 37卷 / 05期

关键词：

D O I：

10.1002/jhet.5570370527

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 6-chloropyrimidines with diethyl [(2-aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5-substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (HSV-1 and HSV-2) and human immunodeficiency virus (HIV-1). Some compounds showed weak antiviral activity against HSV-1.

引用

收藏

页码：1187 / 1191

页数：5

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