Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by Osa

被引：40

作者：

Heitzler, P ^{[1
]}

Vanolst, L ^{[1
]}

Biryukova, I ^{[1
]}

Ramain, P ^{[1
]}

机构：

[1] ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

来源：

GENES & DEVELOPMENT | 2003年 / 17卷 / 05期

关键词：

transcription; enhancer-promoter communication; chromatin; Osa;

D O I：

10.1101/gad.255703

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The GATA factor Pannier activates proneural achaete/scute (ac/sc) expression during development of the sensory organs of Drosophila through enhancer binding. Chip bridges Pannier with the (Ac/Sc)-Daughterless heterodimers bound to the promoter and facilitates the enhancer-promoter communication required for proneural development. We show here that this communication is regulated by Osa, which is recruited by Pannier and Chip. Osa belongs to Brahma chromatin remodeling complexes and we show that Osa negatively regulates ac/sc. Consequently, Pannier and Chip also play an essential role during repression of proneural gene expression. Our study suggests that altering chromatin structure is essential for regulation of enhancer-promoter communication.

引用

页码：591 / 596

页数：6