The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle

被引：44

作者：

Kramer, J ^{[1
]}

Hawley, RS ^{[1
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/ncb944

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mutations in the aberrant X segragation (Axs) gene disrupt the segregation of achiasmate chromosomes during female meiosis in Drosophila melanogaster. We show that Axs encodes the founding member of an eukaryotic family of transmembrane proteins. Axs protein colocalizes with components of the endoplasmic reticulum and is present within a structure ensheathing the meiotic spindle. In both meiotic and mitotic cells, Axs is recruited to the microtubules of assembling spindles. We propose that Axs and the sheath represent novel mediators of meiotic spindle assembly and chromosome segregation.

引用

页码：261 / 263

页数：3

共 12 条

[1] The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions [J].