New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study

被引：84

作者：

Nakajima, Masahiro ^{[1
]}

Takahashi, Atsushi ^{[2
]}

Kou, Ikuyo ^{[1
]}

Rodriguez-Fontenla, Cristina ^{[3
,4
]}

Gomez-Reino, Juan J. ^{[3
,4
,5
]}

Furuichi, Tatsuya ^{[1
]}

Dai, Jin ^{[1
,6
]}

Sudo, Akihiro ^{[7
]}

Uchida, Atsumasa ^{[7
]}

Fukui, Naoshi ^{[8
]}

Kubo, Michiaki ^{[9
]}

Kamatani, Naoyuki ^{[2
]}

Tsunoda, Tatsuhiko ^{[10
]}

Malizos, Konstantinos N. ^{[11
,12
]}

Tsezou, Aspasia ^{[13
]}

Gonzalez, Antonio ^{[3
,4
]}

Nakamura, Yusuke ^{[14
]}

Ikegawa, Shiro ^{[1
]}

机构：

[1] RIKEN, Ctr Genom Med, Lab Bone & Joint Dis, Tokyo, Japan

[2] RIKEN, Ctr Genom Med, Lab Stat Anal, Tokyo, Japan

[3] Hosp Clin Univ Santiago, Lab Invest 10, Santiago De Compostela, Spain

[4] Hosp Clin Univ Santiago, Rheumatol Unit, Santiago De Compostela, Spain

[5] Univ Santiago de Compostela, Dept Med, Santiago De Compostela, Spain

[6] Nanjing Univ, Sch Med, Drum Tower Hosp, Ctr Diag & Treatment Joint Dis, Nanjing 210008, Peoples R China

[7] Mie Univ, Fac Med, Dept Orthopaed Surg, Tsu, Mie, Japan

[8] Natl Hosp Org Sagamihara Natl Hosp, Clin Res Ctr Rheumatol & Allergy, Dept Pathomech, Kanagawa, Japan

[9] RIKEN, Ctr Genom Med, Lab Genotyping Dev, Kanagawa, Japan

[10] RIKEN, Ctr Genom Med, Lab Med Informat, Kanagawa, Japan

[11] Univ Thessaly, Dept Orthopaed, Larisa, Greece

[12] Inst Biomed Res & Technol, Larisa, Greece

[13] Univ Thessaly, Sch Med, Dept Biol, Larisa, Greece

[14] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Tokyo, Japan

来源：

PLOS ONE | 2010年 / 5卷 / 03期

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISM; INCREASES SUSCEPTIBILITY; ARTICULAR CHONDROCYTES; OSTEO-ARTHRITIS; GENE; JAPANESE; PHENOTYPES; ANTIGENS; HLA-DQA2; BTNL2;

D O I：

10.1371/journal.pone.0009723

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of similar to 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43x10(-8) for rs7775228 and 6.73x10(-8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

引用

页数：6

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