The birth and postnatal development of purinergic signalling

被引：107

作者：

Burnstock, G. ^{[1
]}

Fredholm, B. B. ^{[2
]}

North, R. A. ^{[3
]}

Verkhratsky, A. ^{[3
]}

机构：

[1] Royal Free & Univ Coll Med Sch, Auton Neurosci Ctr, London NW3 2PF, England

[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

[3] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

来源：

ACTA PHYSIOLOGICA | 2010年 / 199卷 / 02期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

adenosine; ATP; co-transmission; history; purinergic signalling; purinoceptors; ADENOSINE A(1) RECEPTORS; CENTRAL-NERVOUS-SYSTEM; INTRACELLULAR CALCIUM-CONCENTRATION; DEPOLARIZATION-INDUCED RELEASE; FAST SYNAPTIC-TRANSMISSION; NITRIC-OXIDE SYNTHASE; CYCLIC-AMP PRODUCTION; PAROTID ACINAR-CELLS; ISOLATED PORTAL-VEIN; DORSAL-HORN NEURONS;

D O I：

10.1111/j.1748-1716.2010.02114.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The purinergic signalling system is one of the most ancient and arguably the most widespread intercellular signalling system in living tissues. In this review we present a detailed account of the early developments and current status of purinergic signalling. We summarize the current knowledge on purinoceptors, their distribution and role in signal transduction in various tissues in physiological and pathophysiological conditions.

引用

页码：93 / 147

页数：55

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