Small angle X-ray scattering and 31P NMR studies on the phase behavior of phospholipid bilayered mixed micelles

被引：46

作者：

Bolze, J

Fujisawa, T

Nagao, T

Norisada, K

Saitô, H

Naito, A ^{[1
]}

机构：

[1] Himeji Inst Technol, Dept Life Sci, Kamigoricho, Hyogo 6781297, Japan

[2] RIKEN, Harima Inst SPring 8, Struct Biophys Lab, Mikazukicho, Hyogo 6798145, Japan

[3] RIKEN, Harima Inst SPring 8, Struct Biochem Lab, Mikazukicho, Hyogo 6798145, Japan

来源：

CHEMICAL PHYSICS LETTERS | 2000年 / 329卷 / 3-4期

关键词：

D O I：

10.1016/S0009-2614(00)01029-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The phase behavior of lipid bilayered micelles ('bicelles') (dimyristoyl-phosphatidylcholine, DMPC/dihexanoylphosphatidyl-choline, DHPC 2.6/1) has been studied by small angle X-ray scattering and P-31 NMR. Below 3% w/v the bilayers are arranged in tightly packed stacks. At intermediate concentrations single units are observed, whereas at 24% w/v and higher, weak stacking occurs again. The DMPC/DHPC ratio in the bicelles strongly increases at low concentration, which is correlated with an increase in the bicelle size and stacking. The increase of the order parameter in a magnetic field is related to the stack formation. Below 297 K there is no stacking at any concentration and no magnetic alignment. (C) 2000 Elsevier Science B,V. All rights reserved.

引用

页码：215 / 220

页数：6

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