A genomic view of helper T cell subsets

被引：28

作者：

Rogge, L ^{[1
]}

机构：

[1] Inst Pasteur, Dept Immunol, Immunoregulat Lab, F-75724 Paris 15, France

来源：

MICROARRAYS, IMMUNE RESPONSES AND VACCINES | 2002年 / 975卷

关键词：

lymphocytes; Th1/Th2; cells; oligonucleotide microarrays; adhesion molecules; cell trafficking; inflammation;

D O I：

10.1111/j.1749-6632.2002.tb05941.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genomic-scale gene expression profiling in combination with the availability of a draft sequence of the human genome is beginning to revolutionize the way immunology is done. The possibility of measuring levels of gene expression for tens of thousands of genes simultaneously and in a quantitative fashion aids in the definition of a comprehensive molecular phenotype of cells and cellular processes of the immune system in health and disease. T helper lymphocytes are an essential element of appropriate immune responses to pathogens. To achieve effective immunity, T helper cells differentiate into at least two specialized subsets that direct type 1 and type 2 immune responses. Here, I discuss recent progress that has been made in our understanding of the genetic program that controls the development and functional properties of helper T cell subsets.

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收藏

页码：57 / 67

页数：11

相关论文

共 55 条

[21] DEVELOPMENT OF TH1 CD4+ T-CELLS THROUGH IL-12 PRODUCED BY LISTERIA-INDUCED MACROPHAGES [J].

HSIEH, CS ;

MACATONIA, SE ;

TRIPP, CS ;

WOLF, SF ;

OGARRA, A ;

MURPHY, KM .

SCIENCE, 1993, 260 (5107) :547-549

[22] DIFFERENTIAL REGULATION OF T-HELPER PHENOTYPE DEVELOPMENT BY INTERLEUKIN-4 AND INTERLEUKIN-10 IN AN ALPHA-BETA-T-CELL-RECEPTOR TRANSGENIC SYSTEM [J].

HSIEH, CS ;

HEIMBERGER, AB ;

GOLD, JS ;

OGARRA, A ;

MURPHY, KM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :6065-6069

[23] INTERLEUKIN-12 SIGNALING IN T-HELPER TYPE-1 (TH1) CELLS INVOLVES TYROSINE PHOSPHORYLATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT)3 AND STAT4 [J].

JACOBSON, NG ;

SZABO, SJ ;

WEBERNORDT, RM ;

ZHONG, Z ;

SCHREIBER, RD ;

DARNELL, JE ;

MURPHY, KM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) :1755-1762

[24] Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice [J].

Kaplan, MH ;

Sun, YL ;

Hoey, T ;

Grusby, MJ .

NATURE, 1996, 382 (6587) :174-177

[25] Regulation of T cell immunity by dendritic cells [J].

Lanzavecchia, A ;

Sallusto, F .

CELL, 2001, 106 (03) :263-266

[26]

Lederer JA, 1996, J IMMUNOL, V156, P56

[27] Gene expression profile of aging and its retardation by caloric restriction [J].

Lee, CK ;

Klopp, RG ;

Weindruch, R ;

Prolla, TA .

SCIENCE, 1999, 285 (5432) :1390-1393

[28] T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells [J].

Lighvani, AA ;

Frucht, DM ;

Jankovic, D ;

Yamane, H ;

Aliberti, J ;

Hissong, BD ;

Nguyen, BV ;

Gadina, M ;

Sher, A ;

Paul, WE ;

O'Shea, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) :15137-15142

[29] IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses [J].

Magram, J ;

Connaughton, SE ;

Warrier, RR ;

Carvajal, DM ;

Wu, CY ;

Ferrante, J ;

Stewart, C ;

Sarmiento, U ;

Faherty, DA ;

Gately, MK .

IMMUNITY, 1996, 4 (05) :471-481

[30] NATURAL-KILLER-CELL STIMULATORY FACTOR (INTERLEUKIN-12 [IL-12]) INDUCES T-HELPER TYPE-1 (TH1)-SPECIFIC IMMUNE-RESPONSES AND INHIBITS THE DEVELOPMENT OF IL-4-PRODUCING TH CELLS [J].

MANETTI, R ;

PARRONCHI, P ;

GIUDIZI, MG ;

PICCINNI, MP ;

MAGGI, E ;

TRINCHIERI, G ;

ROMAGNANI, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (04) :1199-1204

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