Synthesis of (+)-prelactone B

被引：38

作者：

Chakraborty, TK ^{[1
]}

Tapadar, S ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 12期

关键词：

prelactone B; sharpless kinetic resolution; epoxide opening; 2-methyl-1,3-diol;

D O I：

10.1016/S0040-4039(03)00326-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radical-mediated opening of a trisubstituted epoxy alcohol using cp(2)TiCl was followed by diastereoselective reduction of the resulting product with a centrally located methylene group, flanked on both sides by two chiral hydroxyl-bearing carbons, to build all the three chiral centers of (+)-prelactone B 1 in their desired stereochemistries leading to the total synthesis of the molecule. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2541 / 2543

页数：3

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