Synthesis and characterization of acrylic acid-containing dextran hydrogels

被引：50

作者：

Chiu, HC ^{[1
]}

Wu, AT ^{[1
]}

Lin, YF ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem Engn, Taichung 402, Taiwan

来源：

POLYMER | 2001年 / 42卷 / 04期

关键词：

dextran hydrogels; pH-dependent swelling; enzymatic degradability;

D O I：

10.1016/S0032-3861(00)00523-1

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

pH-Sensitive dextran hydrogels were prepared by free radical polymerization of methacrylate derivatized dextran, acrylic acid and N-t-butylacrylamide. Incorporation of acrylic acid in hydrogels was confirmed by Fourier transform infrared spectroscopy. The pH-dependent swelling of hydrogels was strongly influenced by the acrylic acid content, conjugation degree of methacrylate moiety with dextran and modified dextran concentration. Intermolecular polymerization that occurred to a greater extent with a lower degree of conjugation of methacrylate and/or higher concentration of modified dextran effectively increased the network density of hydrogels. An increase of acrylic acid reduced the enzymatic degradability of pre-swollen hydrogels by dextranase, although the increased equilibrium swelling was observed. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1471 / 1479

页数：9

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