Structure and function of the atypical orphan nuclear receptor small heterodimer partner

被引：56

作者：

Lee, Yong-Soo ^{[1
]}

Chanda, Dipanjan ^{[1
]}

Sim, Jeonggu ^{[1
]}

Park, Yun-Yong ^{[1
]}

Choi, Hueng-Sik ^{[1
]}

机构：

[1] Chonnam Natl Univ, Hormone Res Ctr, Sch Biol Sci & Technol, Kwangju 700757, South Korea

来源：

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 261 | 2007年 / 261卷

关键词：

orphan nuclear receptor; small heterodimer partner; NR0B2; nuclear receptor; transcription factor;

D O I：

10.1016/S0074-7696(07)61003-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The small heterodimer partner (SHP; NROB2) is a member of the nuclear receptor superfamily and is classified as an "orphan" subgroup, as its ligand has not yet been identified. SHP lacks the classical DNA-binding domain found in most nuclear receptors and functions as a transcriptional coregulator by directly interacting with nuclear receptors and other transcription factors. SHP regulates the transcription of a variety of target genes and controls a variety of physiological functions. For the past 10 years, great progress has been made in our understanding of the mechanism of action of SHP and the regulation of SHP gene expression. Many of the results imply that SHP has a variety of roles in the regulation of metabolic homeostasis. In this review, we discuss the current state of understanding of the structure, expression, and function of the orphan nuclear receptor, SHP.

引用

页码：117 / 158

页数：42

共 109 条

[41] Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene [J].

Jung, D ;

Hagenbuch, B ;

Fried, M ;

Meier, PJ ;

Kullak-Ublick, GA .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2004, 286 (05) :G752-G761

[42] Hepatocyte nuclear factor 1α:: A key mediator of the effect of bile acids on gene expression [J].

Jung, D ;

Kullak-Ublick, GA .

HEPATOLOGY, 2003, 37 (03) :622-631

[43] The nuclear bile acid receptor FXR is activated by PGC-1α in a ligand-dependent manner [J].

Kanaya, E ;

Shiraki, T ;

Jingami, H .

BIOCHEMICAL JOURNAL, 2004, 382 (03) :913-921

[44] The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor α-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal β-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase [J].

Kassam, A ;

Capone, JP ;

Rachubinski, RA .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2001, 176 (1-2) :49-56

[45] Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP [J].

Kemper, JK ;

Kim, H ;

Miao, J ;

Bhalla, S ;

Bae, Y .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (17) :7707-7719

[46] Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis [J].

Kerr, TA ;

Saeki, S ;

Schneider, M ;

Schaefer, K ;

Berdy, S ;

Redder, T ;

Shan, B ;

Russell, DW ;

Schwarz, M .

DEVELOPMENTAL CELL, 2002, 2 (06) :713-720

[47] Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1 [J].

Kim, HJ ;

Kim, JY ;

Park, YY ;

Choi, HS .

NUCLEIC ACIDS RESEARCH, 2003, 31 (23) :6860-6872

[48] Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1 [J].

Kim, HJ ;

Kim, JY ;

Park, SK ;

Seo, JH ;

Kim, JB ;

Lee, IK ;

Kim, KS ;

Choi, HS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (27) :28122-28131

[49] Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/NeuroD [J].

Kim, JY ;

Chu, K ;

Kim, HJ ;

Seong, HA ;

Park, KC ;

Sanyal, S ;

Takeda, J ;

Ha, HJ ;

Shong, MH ;

Tsai, MJ ;

Choi, HS .

MOLECULAR ENDOCRINOLOGY, 2004, 18 (04) :776-790

[50] Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding [J].

Kim, JY ;

Kim, HJ ;

Kim, KT ;

Park, YY ;

Seong, HA ;

Park, KC ;

Lee, IK ;

Ha, H ;

Shong, M ;

Park, SC ;

Choi, HS .

MOLECULAR ENDOCRINOLOGY, 2004, 18 (12) :2880-2894

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