Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD

被引：131

作者：

Yasui, K ^{[1
]}

Kowa, H ^{[1
]}

Nakaso, K ^{[1
]}

Takeshima, T ^{[1
]}

Nakashima, K ^{[1
]}

机构：

[1] Tottori Univ, Fac Med, Inst Neurol Sci, Div Neurol, Yonago, Tottori 6838504, Japan

来源：

NEUROLOGY | 2000年 / 55卷 / 03期

关键词：

D O I：

10.1212/WNL.55.3.437

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Plasma homocysteine and cysteine levels were measured in 90 patients with PD with the MTHFR C677T (T/T) genotype. The authors found that the levels of homocysteine-a possible risk factor for vascular disease-were elevated by 60% in levodopa-treated patients with PD, with the most marked elevation occurring in patients with the T/T genotype. Cysteine levels in subjects with PD did not differ from levels in control subjects, In the T/T genotype patients, homocysteine and folate levels were inversely correlated. Increased homocysteine might be related to levodopa, MTHFR genotype, and folate in PD.

引用

页码：437 / 440

页数：4

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