Pneumolysin is a key factor in misidentification of macrolide-resistant Streptococcus pneumoniae and is a putative virulence factor of S-mitis and other streptococci

被引：35

作者：

Neeleman, C

Klaassen, CHW

Klomberg, DM

de Valk, HA

Mouton, JW

机构：

[1] Canisius Wilhelmina Ziekenhuis Nijmegen, Dept Med Microbiol & Infect Dis, NL-6532 SZ Nijmegen, Netherlands

[2] Univ Nijmegen St Radboud Hosp, Dept Intens Care Med, NL-6500 HB Nijmegen, Netherlands

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2004年 / 42卷 / 09期

关键词：

D O I：

10.1128/JCM.42.9.4355-4357.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the applicability of ply PCR for confirmation of the identification of Streptococcus pneumoniae. lytA PCR, 16S rRNA sequencing, and amplified-fragment length polymorphism were used as reference methods. In contrast to the lytA gene, the ply gene proved to be not specific for S. pneumoniae. The presence of the ply gene in other streptococci, in particular Streptococcus mitis, suggests that pneumolysin plays a pathogenic role.

引用

页码：4355 / 4357

页数：3

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