The role of analytical sciences medical systems biology

被引：212

作者：

van der Greef, J

Stroobant, P

van der Heijden, R

机构：

[1] TNO, Syst Biol, NL-3700 AJ Zeist, Netherlands

[2] Beyond Genom Inc, Waltham, MA 02451 USA

[3] Gorlaeus Labs, LACDR, Ctr Med Syst Biol, NL-3700 RA Leiden, Netherlands

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2004年 / 8卷 / 05期

关键词：

D O I：

10.1016/j.cbpa.2004.08.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Medical systems biology has generated widespread interest because of its bold conception and exciting potential, but the field is still in its infancy. Although there has been tremendous progress achieved recently in generating, integrating and analysing data in the medical and pharmaceutical field, many challenges remain, especially with respect to the crucial core technologies required for analytical characterization. This review briefly summarizes these aspects for metabolomics, proteomics, data handling and multivariate biostatistics.

引用

收藏

页码：559 / 565

页数：7

相关论文

共 64 条

[1] The human plasma proteome - History, character, and diagnostic prospects [J].

Anderson, NL ;

Anderson, NG .

MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (11) :845-867

[2] The human plasma proteome - A nonredundant list developed by combination of four separate sources [J].

Anderson, NL ;

Polanski, M ;

Pieper, R ;

Gatlin, T ;

Tirumalai, RS ;

Conrads, TP ;

Veenstra, TD ;

Adkins, JN ;

Pounds, JG ;

Fagan, R ;

Lobley, A .

MOLECULAR & CELLULAR PROTEOMICS, 2004, 3 (04) :311-326

[3] A universal denoising and peak picking algorithm for LC-MS based on matched filtration in the chromatographic time domain [J].

Andreev, VP ;

Rejtar, T ;

Chen, HS ;

Moskovets, EV ;

Ivanov, AR ;

Karger, BL .

ANALYTICAL CHEMISTRY, 2003, 75 (22) :6314-6326

[4] Batch statistical processing of 1H NMR-derived urinary spectral data [J].

Antti, H ;

Bollard, ME ;

Ebbels, T ;

Keun, H ;

Lindon, JC ;

Nicholson, JK ;

Holmes, E .

JOURNAL OF CHEMOMETRICS, 2002, 16 (8-10) :461-468

[5] From functional genomics to systems biology:: Concepts and practices [J].

Auffray, C ;

Imbeaud, S ;

Roux-Rouquié, M ;

Hood, L .

COMPTES RENDUS BIOLOGIES, 2003, 326 (10-11) :879-892

[6] Metabolic profiling of the effects of D-galactosamine in liver spheroids using 1H NMR and MAS-NMR spectroscopy [J].

Bollard, ME ;

Xu, JS ;

Purcell, W ;

Griffin, JL ;

Quirk, C ;

Holmes, E ;

Nicholson, JK .

CHEMICAL RESEARCH IN TOXICOLOGY, 2002, 15 (11) :1351-1359

[7] Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA) [J].

Boros, LG ;

Steinkamp, MP ;

Fleming, JC ;

Lee, WNP ;

Cascante, M ;

Neufeld, EJ .

BLOOD, 2003, 102 (10) :3556-3561

[8] Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics (vol 8, pg 1439, 2002) [J].

Brindle, JT ;

Antti, H ;

Holmes, E ;

Tranter, G ;

Nicholson, JK ;

Bethell, HWL ;

Clarke, S ;

Schofield, PM ;

McKilligin, E ;

Mosedale, DE ;

Grainger, DJ .

NATURE MEDICINE, 2003, 9 (04) :477-477

[9] On-line preconcentration strategies for trace analysis of metabolites by capillary electrophoresis [J].

Britz-McKibbin, P ;

Terabe, S .

JOURNAL OF CHROMATOGRAPHY A, 2003, 1000 (1-2) :917-934

[10] Centering and scaling in component analysis [J].

Bro, R ;

Smilde, AK .

JOURNAL OF CHEMOMETRICS, 2003, 17 (01) :16-33

← 1 2 3 4 5 6 7 →