Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: an evolving story

被引：116

作者：

Stathopoulos, C

Hendrixson, DR

Thanassi, DG

Hultgren, SJ

St Geme, JW

Curtiss, R ^{[2
]}

机构：

[1] Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA

[2] SUNY Stony Brook, Sch Med, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA

[3] SUNY Stony Brook, Sch Med, Ctr Infect Dis, Stony Brook, NY 11794 USA

[4] St Louis Childrens Hosp, Div Infect Dis, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[6] Washington Univ, Dept Biol, St Louis, MO 63110 USA

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 09期

关键词：

Gram-negative bacteria; general secretory pathway; Sec translocase; pullulanase; toxins; pili; curli; autotransporters; S-layers;

D O I：

10.1016/S1286-4579(00)01260-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Secretion of proteins by the general secretory pathway (GSP) is a two-step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pill, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1061 / 1072

页数：12

共 100 条

[91] The PapC usher forms an oligomeric channel: Implications for pilus biogenesis across the outer membrane [J].